⭐Popular

CJC-1295 (without DAC)

Also known as: Modified GRF 1-29, CJC-1295 no DAC

HealthMuscle GrowthSleepAnti-Aging
Not FDA Approved

Primary recreational use: Muscle growth and anti-aging

What is CJC-1295 (without DAC)?

CJC-1295 without DAC, known as Modified GRF 1-29, is a synthetic growth hormone-releasing hormone analog. It was developed to mimic the body's natural GH release patterns and is primarily used for its benefits in restoring natural GH pulsatility. Currently investigational and not FDA-approved, users should be cautious of potential side effects, including injection site reactions and hormone-related issues.

Primary Benefits

Improves sleep quality. Enhances muscle recovery. Promotes fat loss.

How It Works

CJC-1295 without DAC binds to GHRH receptors on somatotroph cells, stimulating cAMP production and promoting GH release in natural pulses. This results in a more physiological secretion pattern compared to its DAC counterpart, hence reducing receptor desensitization risks.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T start with a high dose - begin with the lowest effective dose to assess tolerance.
  • 2.NEVER freeze reconstituted solution - store properly refrigerated.
  • 3.AVOID injection close to meals - administer at least 30 minutes away from food.
  • 4.DON'T use if you have active cancer due to growth-promoting effects.
  • 5.DON'T share injection needles or vials to ensure sterility.
  • 6.AVOID use if experiencing severe side effects like hives or persistent headaches.
  • 7.NEVER purchase from unverified sources due to purity concerns.
  • 8.DON'T ignore signs of possible overdosing like unusual swelling or rapid weight gain.

Who Should NOT Use

  • Active cancer
  • Diabetic retinopathy
  • Severe kidney disease

Use Contexts

Different purposes have different protocols, dosing, and considerations

⚕Off-Label Medical

Natural GH Pulse Restoration

moderate evidence

Used to restore natural pulsatile GH release patterns for anti-aging and wellness purposes.

Evidence: Multiple studies support pulsatile GH restoration via CJC-1295 without DAC, emphasizing its anti-aging potential.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
100-300 mcg
Reported Frequency
twice daily
Reported Cycle
12-16 weeks
Reported Route
Subcutaneous

Timing: Morning and bedtime

Notes: Ensure dosing at least 30 minutes away from meals.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Anti-Aging/Wellness100mcg2x dailySubcutaneous injection

Pharmacokinetics

Half-Life
30 minutes
Time to Peak
15 minutes
Clearance
~2.5 hours

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Injection site reactionscommon (1-10%)
Temporary facial flushingcommon (1-10%)
Injection-Specific Warnings
  • Use sterile technique to prevent infections.

Storage

Temperature
2-8°C
Reconstituted
Use within 30 days
Shelf Life
24 months
Light Sensitive
Yes - protect from light
⚡Recreational

Muscle Growth and Recovery

moderate evidence

Utilized in fitness communities to enhance muscle repair and hypertrophy, particularly after intense exercise.

Evidence: Anecdotal and small-scale studies indicate muscle recovery benefits by promoting GH and IGF1 elevation when combined with appropriate training.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
100-200 mcg
Reported Frequency
twice daily
Reported Cycle
12-16 weeks
Reported Route
Subcutaneous

Timing: Post-workout and bedtime

Notes: Combining with protein-rich meals may augment effects.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Body Composition100-150mcg3x dailySubcutaneous injection

Pharmacokinetics

Half-Life
30 minutes
Time to Peak
15 minutes
Clearance
~2.5 hours

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Facial flushingcommon (1-10%)
Water retentioncommon (1-10%)
Injection-Specific Warnings
  • Rotate injection sites to avoid lipodystrophy.

Storage

Temperature
2-8°C
Reconstituted
Use within 30 days
Shelf Life
24 months
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Risk of contamination from unverified sources
  • Mislabeling of dose strength

Safety Tips

  • Use bacteriostatic water for reconstitution.
  • Clearly label reconstitution date and concentration.

Warning Signs to Stop

  • New or changing skin lesions
  • Unexplained rapid weight gain

Seek Medical Help Immediately If

  • Severe allergic reactions such as hives or difficulty breathing

Frequently Asked Questions

Common questions about CJC-1295 (without DAC)

How long until I see effects?

CJC-1295 without DAC typically shows effects such as improved sleep within 1-2 weeks.

What time of day should I take it?

It's best to take CJC-1295 without DAC in the morning upon waking and before bedtime for optimal hormonal pulsatility.

How can I minimize side effects?

To minimize side effects from CJC-1295 without DAC, ensure proper dosing and administer on an empty stomach.

Does tolerance develop?

Tolerance to CJC-1295 without DAC is minimized due to its pulsatile nature, allowing for sustained effectiveness over cycles.

How should I store it?

Store CJC-1295 without DAC in a refrigerator at 2-8°C and use within 30 days of reconstitution.

Do I need to cycle it?

It's advised to follow a cycle of 12-16 weeks with an optional 2-4 week break to prevent desensitization when using CJC-1295 without DAC.

Reported Combinations

Compounds reported to be used alongside CJC-1295 (without DAC) in community discussions

recreational

Ipamorelin

Synergistic GH release with enhanced IGF-1 effects.

off label-medical

GHRP-2

Augments GH secretion when used with CJC-1295.

recreational

BPC-157

Supports tissue repair and recovery.

Reported Interactions

Interactions reported in literature and community discussions.

Advil/ibuprofenminor

May enhance fluid retention.

Blood pressure medicationsmoderate

Alterations in blood pressure levels may occur.

Insulinmoderate

Monitor blood glucose as CJC-1295 can affect insulin sensitivity.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

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Citations

Last updated: October 5, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

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