🌱Emerging

5-Amino-1MQ

Also known as: 5-amino-1-methylquinolinium, NNMT Inhibitor

Weight LossAnti-AgingHealthPerformance
Not FDA Approved

Primary recreational use: Metabolic enhancement and longevity

What is 5-Amino-1MQ?

5-Amino-1MQ, a small molecule developed for metabolic research, enhances cellular NAD+ levels and mitochondrial function. It's gaining attention for potential anti-aging properties and energy metabolism improvement. While not approved by the FDA, it's used in preclinical research and by those interested in weight loss and longevity. Main concerns include limited human data and potential side effects like nausea and mild headache.

Primary Benefits

Enhances mitochondrial function. Promotes fat loss. Improves energy metabolism.

How It Works

5-Amino-1MQ inhibits the enzyme NNMT, which increases NAD+ availability. This supports mitochondrial function, promotes fat oxidation, and enhances cellular energy metabolism. The compound directly regulates NAD+ levels and downstream metabolic pathways, facilitating improved energy utilization.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T start with a high dose - begin with the lowest effective dose to assess tolerance.
  • 2.NEVER use without consulting with a healthcare provider, especially if you have existing conditions.
  • 3.AVOID using if you are pregnant or breastfeeding.
  • 4.DON'T exceed recommended cycle lengths; take breaks as suggested to prevent tolerance.
  • 5.NEVER mix with alcohol; it may increase side effects.
  • 6.DON'T store improperly; keep away from moisture and light.
  • 7.AVOID using past the expiration date; ensure product quality.
  • 8.NEVER skip breaks between cycles to allow the body to reset.
  • 9.DON'T ignore mild side effects like nausea; reassess dosage if symptoms persist.

Who Should NOT Use

  • Pregnancy
  • Breastfeeding
  • Existing metabolic disorders

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Metabolic research

limited evidence

Research aiming to improve mitochondrial function and enhance metabolic processes through NNMT inhibition.

Evidence: Animal studies show promising effects on fat metabolism and energy expenditure, but human data is lacking.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
50-100 mg
Reported Frequency
once daily
Reported Cycle
4-6 weeks
Reported Route
Subcutaneous

Timing: Morning, fasted

Notes: Dosage may vary based on body weight, typically up to 75 mg for individuals under 200 lbs.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Initial metabolic enhancement50 mg1x dailyOral

Pharmacokinetics

Half-Life
8 hrs
Time to Peak
2 hrs
Clearance
1.7 days

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Mild headachereported (frequency unknown)
Nauseareported (frequency unknown)
Increased alertness/jitterinessreported (frequency unknown)
Serious / Rare
  • Insomnia
Injection-Specific Warnings
  • Monitor injection site reactions
  • Use sterile technique to avoid infections

Storage

Temperature
Cool, dry place
Reconstituted
Not applicable
Shelf Life
Ensure quality until expiration date
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Potential for contamination and impurity due to unregulated sources.
  • Mislabeling or degradation issues during storage.

Safety Tips

  • Ensure sourcing from reputable suppliers with COAs.
  • Use sterile technique if injectable.
  • Start with lowest effective dose for personal tolerance assessment.
  • Store properly to prevent degradation.

Warning Signs to Stop

  • Severe headache
  • Persistent nausea
  • Unusual symptoms or adverse reactions

Seek Medical Help Immediately If

  • Experiencing severe or prolonged insomnia
  • Any signs of allergic reaction

Frequently Asked Questions

Common questions about 5-Amino-1MQ

How long until I see effects?

Effects of 5-Amino-1MQ can start to become noticeable within 1-2 weeks for energy levels, with metabolic improvements seen at 4-8 weeks.

What time of day should I take it?

5-Amino-1MQ is best taken in the morning with food to improve absorption and minimize potential side effects.

How can I minimize side effects?

Start with the lowest effective dose of 5-Amino-1MQ and take it with food to reduce gastrointestinal effects.

Does tolerance develop?

Tolerance to 5-Amino-1MQ is possible; cycling is recommended to prevent this.

How should I store it?

Store 5-Amino-1MQ in a cool, dry place away from light and moisture to maintain its efficacy.

Do I need to cycle it?

Yes, it is advisable to cycle 5-Amino-1MQ, typically 8-12 weeks on followed by 2-4 weeks off.

Reported Combinations

Compounds reported to be used alongside 5-Amino-1MQ in community discussions

recreational

NAD+ Precursors

May enhance NAD+ levels achieved with 5-Amino-1MQ.

recreational

Resveratrol

Supports longevity pathways alongside 5-Amino-1MQ.

recreational

BPC-157

May enhance cellular repair processes.

Reported Interactions

Interactions reported in literature and community discussions.

Alcoholmoderate

May increase potential for adverse side effects such as nausea and dizziness.

Blood pressure medsmoderate

Monitor blood pressure as 5-Amino-1MQ can cause elevation.

Caffeineminor

May enhance jitteriness and alertness effects.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

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Citations

Last updated: October 5, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

If you are experiencing a medical emergency, call emergency services immediately. If you have questions about medications or supplements, consult a licensed pharmacist or physician.