Adipotide (Prohibitin‑TP01)
Also known as: Prohibitin-TP01, TP01
Primary recreational use: Fat loss acceleration
What is Adipotide (Prohibitin‑TP01)?
Adipotide (Prohibitin‑TP01) is an experimental peptidomimetic developed to target prohibitin and annexin A2 on white adipose tissue. It is primarily researched for its potential to induce rapid fat loss by disrupting the blood supply to fat cells. While it demonstrated promising weight loss effects in animal studies, development has been halted due to concerns over kidney safety.
Primary Benefits
Promotes rapid fat loss. Improves insulin sensitivity. Targets white adipose tissue.
How It Works
Adipotide binds to prohibitin and annexin A2 on the endothelium of white adipose tissue, triggering apoptosis in the cells by disrupting mitochondrial membranes. This leads to the selective apoptosis of fat cells after reducing blood supply to these tissues.
Safety Tips
Precautions reported in community discussions and literature. This is not a complete list.
- 1.DON'T use if you have kidney issues, due to potential nephrotoxic effects.
- 2.DON'T exceed the typical dosing range of 0.10-0.75 mg/kg daily.
- 3.AVOID dehydration during treatment to minimize kidney risk.
- 4.NEVER use without monitoring kidney function, such as serum creatinine.
- 5.DON'T inject into the same site repeatedly without rotation.
Use Contexts
Different purposes have different protocols, dosing, and considerations
Adipose Mass Reduction
moderate evidenceUsed to target and reduce white adipose tissue in the body for weight loss and improved metabolic health.
Evidence: Phase 1 trials and animal studies support its effectiveness in fat reduction and metabolic improvement.
The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.
Timing: Administer at the same time daily, preferably in the morning.
Community-Reported Protocols
Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.
| Reported Goal | Reported Dose | Reported Frequency | Reported Route |
|---|---|---|---|
| Primate research replication | 0.43 mg/kg | once daily | Subcutaneous injection |
| Dose-finding (research) | 0.10–0.75 mg/kg | once daily | Subcutaneous (escalating tiers) |
Pharmacokinetics
Reported Side Effects
This is not a complete list. Other side effects may occur.
Common
Serious / Rare
- Renal impairment (dose-dependent, reversible)
Injection-Specific Warnings
- Proper site rotation recommended to avoid irritation
Storage
Harm Reduction Information
Quality Concerns
- Potential contamination due to improper handling
Safety Tips
- Use sterile technique during reconstitution and injection.
- Rotate injection sites to decrease local irritation.
- Begin with the lowest dose to assess tolerance.
Warning Signs to Stop
- Persistent creatinine elevation
- Signs of renal impairment
Seek Medical Help Immediately If
- Severe kidney pain
- High fever post-injection
Frequently Asked Questions
Common questions about Adipotide (Prohibitin‑TP01)
How long until I see effects?
With Adipotide, fat loss may become visible within 2-4 weeks, based on animal studies.
What time of day should I take it?
Adipotide should be administered daily at a consistent time, preferably in the morning.
How can I minimize side effects?
To minimize side effects from Adipotide, ensure proper hydration and conduct regular kidney function tests.
Does tolerance develop?
There is no known indication of tolerance development with Adipotide, but its use should be cautiously monitored.
How should I store it?
Adipotide should be stored at 2–8°C in a refrigerator, and properly labeled after reconstitution.
Do I need to cycle it?
Adipotide is typically used in 28-day cycles with an extended break to monitor effects and side effects.
Reported Combinations
Compounds reported to be used alongside Adipotide (Prohibitin‑TP01) in community discussions
Semaglutide
Both target metabolic health and can improve weight loss when monitored properly.
BPC-157
Supports tissue health and may aid recovery during adipose reduction.
CJC-1295
May enhance metabolic outcomes due to GH synergism.
Reported Interactions
Interactions reported in literature and community discussions.
Avoid using with nephrotoxic drugs to prevent kidney damage.
Monitor combination; simultaneous use may necessitate renal function monitoring.
No major interaction, but monitor hydration.
Reconstitution Calculator
100 units = 1 mL
Safety Tips
- Always consult a licensed medical professional for dosing and reconstitution instructions.
- Always double check your units. Mixing up mg and mcg can be very dangerous.
- Make sure to select your syringe type. U-100 and U-50 syringes have different units.
- Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.
This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.
Legal Status by Region
Regulatory status varies by country
USA
investigational
UK
investigational
EU
investigational
Australia
investigational
Canada
investigational
Explore More Research
Browse our database of peptide research information compiled from published literature and community sources.