⭐Popular

AHK-Cu

Also known as: Copper Tripeptide-3, Tripeptide-3, Ala-His-Lys Copper

Hair GrowthSkin Health
Not FDA Approved

Primary recreational use: Hair Growth

What is AHK-Cu?

AHK-Cu, a synthetic copper-binding tripeptide, was developed to stimulate hair growth and support skin regeneration. It primarily targets hair follicles, promoting elongation and dermal papilla cell proliferation. Despite its promising applications, it remains unapproved by the FDA and is used mainly in cosmetic products. Key concerns include risks of skin irritation and copper toxicity when combined with other copper sources.

Primary Benefits

Stimulates hair growth. Promotes skin regeneration.

How It Works

AHK-Cu binds to hair follicle dermal cells, enhancing dermal papilla cell proliferation and VEGF production. It inhibits TGF-β1, extending the anagen phase of hair growth and stimulates collagen synthesis for skin regeneration.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T apply without performing a patch test, especially if you have sensitive skin.
  • 2.AVOID using with other acidic products like AHAs and Vitamin C to prevent degradation.
  • 3.NEVER combine with additional copper supplements due to risk of copper toxicity.
  • 4.DON'T use on broken or infected skin to avoid irritation.
  • 5.DON'T apply near the eyes as it may cause irritation or discomfort.

Who Should NOT Use

  • Wilson's disease

Use Contexts

Different purposes have different protocols, dosing, and considerations

⚡Recreational

Hair Growth

limited evidence

Used to promote hair follicle elongation and increase hair density.

Evidence: Community and anecdotal reports mainly support its efficacy, lacking formal clinical trials.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
0.5-1 mg
Reported Frequency
twice daily
Reported Cycle
12-24 weeks
Reported Route
Subcutaneous

Timing: Evening application preferred

Notes: Often combined with minoxidil for enhanced effects.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Initate Hair Growth0.5-1% solution/serumTwice dailyTopical to scalp

Pharmacokinetics

Half-Life
NA
Time to Peak
NA
Clearance
NA

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Skin irritationcommon (1-10%)
Allergic reactionsuncommon (0.1-1%)
Serious / Rare
  • Copper toxicity
Injection-Specific Warnings
  • Maintain sterile technique during reconstitution and applications.

Storage

Temperature
Refrigerate at 2-8°C
Reconstituted
Use within 30 days
Shelf Life
NA
Light Sensitive
Yes - protect from light
⚡Recreational

Skin Health

limited evidence

Used to improve skin firmness and elasticity, reducing visible signs of aging.

Evidence: Many users report improved skin texture with continued use, supported by minor studies.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
0.3-1 mg
Reported Frequency
twice daily
Reported Cycle
8-16 weeks
Reported Route
Subcutaneous

Timing: Evening application preferred

Notes: Apply to clean, dry skin for best absorption.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Enhance Skin Quality0.3-1% in serum/creamTwice dailyTopical to skin

Pharmacokinetics

Half-Life
NA
Time to Peak
NA
Clearance
NA

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Skin irritationcommon (1-10%)
Serious / Rare
  • NA
Injection-Specific Warnings
  • Avoid using with exogenous copper supplements.

Storage

Temperature
Refrigerate at 2-8°C
Reconstituted
Use within 30 days
Shelf Life
NA
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Purity and mislabeling risks due to lack of regulation

Safety Tips

  • Use sterile technique when reconstituting and applying.
  • Patch test on a small area to check for skin reactions before full use.
  • Apply in the evening to limit degradation from UV exposure.

Warning Signs to Stop

  • If severe skin irritation occurs, discontinue use.
  • Stop if signs of copper toxicity, such as nausea or vomiting, occur.

Seek Medical Help Immediately If

  • Seek help if experiencing severe allergic reactions with swelling or difficulty breathing.

Frequently Asked Questions

Common questions about AHK-Cu

How long until I see effects?

AHK-Cu generally takes 3-6 months for visible results in hair growth and 4-8 weeks for skin improvements.

What time of day should I apply it?

AHK-Cu is best applied in the evening to avoid UV exposure, which can degrade the peptide.

How can I minimize side effects?

To minimize side effects with AHK-Cu, avoid using it with acidic products and perform a patch test before full application.

Does tolerance develop?

AHK-Cu has no reported issues with tolerance development when used consistently.

How should I store it?

Store AHK-Cu refrigerated at 2-8°C, and protect from light to maintain stability.

Do I need to cycle it?

AHK-Cu does not typically require cycling and can be used continuously for best results.

Can I combine it with other peptides?

Yes, AHK-Cu can be synergistic with other peptides like GHK-Cu and BPC-157 for enhanced effects.

Reported Combinations

Compounds reported to be used alongside AHK-Cu in community discussions

recreational

GHK-Cu

Enhances regenerative effects on skin and hair follicles.

recreational

Minoxidil

Promotes hair growth through synergistic mechanisms.

recreational

BPC-157

Supports regeneration and healing.

Reported Interactions

Interactions reported in literature and community discussions.

Copper supplementsmajor

Increased risk of copper toxicity.

Vitamin Cmoderate

Requires timing; may degrade AHK-Cu.

AHA/BHA acidsmoderate

May degrade peptide when used concurrently.

Propranololmoderate

Potential interaction; monitor for increased effects.

Minoxidilminor

May have a synergistic effect, enhancing hair growth.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 5, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

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