Ara 290
Also known as: Cibinetide
Primary recreational use: Nerve regeneration
What is Ara 290?
Ara 290, also known as Cibinetide, is an engineered 11-amino acid peptide derived from erythropoietin. It primarily targets the Innate Repair Receptor to offer tissue-protective and anti-inflammatory effects without promoting red blood cell production. Ara 290 is in Phase II/III trials with Orphan Drug designation for conditions like sarcoidosis and diabetic neuropathy in the US and EU. While deemed safe in studies, it is not FDA approved, and users should be cautious about potential injection site reactions and ensure correct handling and storage.
Primary Benefits
Nerve regeneration. Anti-inflammatory effects. Tissue protection.
How It Works
Ara 290 activates the Innate Repair Receptor (IRR), a heterodimer of the EPOR and CD131, found on damaged tissues. Activation of this receptor initiates anti-apoptotic, anti-inflammatory, and tissue-protective pathways, leading to nerve regeneration and tissue repair without affecting erythropoiesis.
Safety Tips
Precautions reported in community discussions and literature. This is not a complete list.
- 1.DON'T start with a high dose - begin with the lowest effective dose to assess tolerance.
- 2.NEVER use if you have received anti-TNF or EPO therapy within the last 6 months.
- 3.AVOID using during pregnancy or if you have a BMI over 34 kg/m².
- 4.DON'T store the reconstituted solution at room temperature for more than 24 hours.
- 5.DON'T freeze the reconstituted peptide, and always protect it from light.
Use Contexts
Different purposes have different protocols, dosing, and considerations
Diabetic Neuropathy Treatment
moderate evidenceStudied for improving neuropathy symptoms in diabetes, showing benefits in clinical and preclinical trials.
Evidence: Multiple Phase II/III clinical trials and studies demonstrate effectiveness in diabetic neuropathy.
The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.
Timing: Morning
Notes: Clinical use focuses on consistent daily dosing for optimal results.
Community-Reported Protocols
Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.
| Reported Goal | Reported Dose | Reported Frequency | Reported Route |
|---|---|---|---|
| Neuropathy Treatment | 4 mg daily | once daily | Subcutaneous injection |
Pharmacokinetics
Reported Side Effects
This is not a complete list. Other side effects may occur.
Common
Injection-Specific Warnings
- Rotate injection sites to avoid irritation
Storage
Sarcoidosis-Related Small Fiber Neuropathy
strong evidenceOrphan drug designation for small fiber neuropathy associated with sarcoidosis, in clinical trials to reduce pain and improve nerve function.
Evidence: Orphan Drug Designation indicates substantial evidence for efficacy in this specific neuropathy.
The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.
Timing: Morning
Notes: Follow clinical protocols for dose and frequency.
Community-Reported Protocols
Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.
| Reported Goal | Reported Dose | Reported Frequency | Reported Route |
|---|---|---|---|
| Sarcoidosis Neuropathy | 1-8 mg daily | once daily | Subcutaneous injection |
Pharmacokinetics
Reported Side Effects
This is not a complete list. Other side effects may occur.
Storage
Harm Reduction Information
Quality Concerns
- Sterility must be ensured during reconstitution
- Proper light protection is essential
Safety Tips
- Always use bacteriostatic water for reconstitution
- Sterile technique is crucial to avoid contamination
- Rotate injection sites to minimize irritation
Warning Signs to Stop
- Severe injection site reactions
- Signs of severe allergic reaction
Seek Medical Help Immediately If
- Unexpected severe side effects
- Signs of infection at injection site
Frequently Asked Questions
Common questions about Ara 290
How long until I see effects?
For Ara 290, users typically begin to observe initial effects within 1 to 2 weeks, with peak benefits around 4 to 6 weeks.
What time of day should I take it?
Ara 290 should be taken consistently at the same time each day, preferably in the morning, to align with circadian rhythms for optimal results.
How can I minimize side effects?
To minimize side effects from Ara 290, rotate injection sites and use a sterile technique when preparing and administering the injection.
Does tolerance develop?
There is no significant evidence suggesting tolerance development to Ara 290, but cycling and monitoring are recommended.
How should I store it?
Store Ara 290 refrigerated at 2-8°C and protect it from light. Once reconstituted, use it immediately or within 24 hours.
Do I need to cycle it?
Ara 290 is typically used in 28-day cycles, with breaks between cycles varying based on specific health indications.
Reported Combinations
Compounds reported to be used alongside Ara 290 in community discussions
BPC-157
Enhances tissue repair and regenerative processes
TB-500
Works synergistically in tissue healing
Thymosin Beta-4
Complementary mechanisms in promoting recovery
Reported Interactions
Interactions reported in literature and community discussions.
Increases risk of adverse effects due to similar pathways.
Avoid due to possible interaction and reduced efficacy.
Use caution, as combined effects on tissue repair need monitoring.
Reconstitution Calculator
100 units = 1 mL
Safety Tips
- Always consult a licensed medical professional for dosing and reconstitution instructions.
- Always double check your units. Mixing up mg and mcg can be very dangerous.
- Make sure to select your syringe type. U-100 and U-50 syringes have different units.
- Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.
This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.
Legal Status by Region
Regulatory status varies by country
USA
legal for research
UK
legal for research
EU
legal for research
Australia
legal for research
Canada
legal for research
Explore More Research
Browse our database of peptide research information compiled from published literature and community sources.
Citations
Last updated: October 5, 2023