🌱Emerging

Dihexa

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408

CognitiveHealth
Not FDA Approved

Primary recreational use: Cognitive enhancement and memory improvement

What is Dihexa?

Dihexa is a synthetic oligopeptide originally developed at Washington State University for the treatment of Alzheimer's disease. It is known for its potent cognitive-enhancing effects, promoting synaptogenesis and crossing the blood-brain barrier effectively. Although it is not approved by the FDA and remains a research compound, it is investigated for its potential in neuroprotection and cognitive recovery. However, there are significant concerns about its long-term safety, particularly regarding tumorigenesis due to c-Met activation.

Primary Benefits

Enhances cognitive function. Promotes synaptogenesis. Offers neuroprotection.

How It Works

Dihexa binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at the c-Met receptor, activating the PI3K/AKT pathway. This enhances synaptic connections by promoting dendritic spine formation and supports neuronal survival.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T start with a high dose - begin with the lowest effective dose to assess tolerance.
  • 2.DON'T ignore side effects like anxiety and nervousness - adjust use accordingly.
  • 3.DON'T use Dihexa if you have a history of cancer or are pregnant.
  • 4.DON'T skip cycling - use in cycles of 4-8 weeks with breaks to prevent tolerance.
  • 5.DON'T store injectable forms improperly - refrigerate as needed.

Who Should NOT Use

  • History of cancer
  • Pregnancy
  • Breastfeeding

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Cognitive enhancement

limited evidence

Dihexa is used for improving cognitive functions such as memory and learning, primarily in research settings.

Evidence: Primarily based on animal studies with some anecdotal reports from cognitive enhancement communities.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
0.5-1 mg/kg
Reported Frequency
once daily
Reported Cycle
4-8 weeks
Reported Route
Subcutaneous, Intramuscular

Timing: Morning

Notes: Intraperitoneal injections are commonly used in research.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Cognitive enhancement0.5mg/kg1x dailyIntraperitoneal

Pharmacokinetics

Half-Life
12 hrs
Time to Peak
2 hrs
Clearance
2.5 days

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Headachesvery common (>10%)
Anxietycommon (1-10%)
Serious / Rare
  • Potential tumor development via c-Met activation
Injection-Specific Warnings
  • Injection site reactions possible

Storage

Temperature
Refrigerated
Reconstituted
Use within 30 days
Shelf Life
30 days post-reconstitution
Light Sensitive
No

Harm Reduction Information

Quality Concerns

  • Potential for contamination if sourced from unverified suppliers
  • Lack of standardized purity from non-pharmaceutical sources

Safety Tips

  • Use accurate dosing equipment to measure Dihexa doses.
  • Avoid taking Dihexa late in the day but preferably in the morning.
  • Ensure injectable form is prepared with sterile techniques.

Warning Signs to Stop

  • New or worsening anxiety
  • Severe headaches
  • Sleeping disturbances

Seek Medical Help Immediately If

  • Severe anxiety or panic attacks
  • Unexplained bleeding
  • Signs of an allergic reaction

Frequently Asked Questions

Common questions about Dihexa

How long until I see effects?

Effects from Dihexa may start to be noticeable within 1-3 weeks, with full benefits potentially peaking around 4-8 weeks.

What time of day should I take it?

Dihexa is best taken in the morning to align with peak cognitive demands and avoid potential sleep disturbances.

How can I minimize side effects?

To minimize Dihexa side effects, start with a low dose, avoid taking it too late in the day, and adjust dosage based on your response.

Does tolerance develop?

Yes, tolerance to Dihexa can develop, which is why cycling with breaks of 2-4 weeks is recommended.

How should I store it?

Dihexa should be stored at room temperature if oral and refrigerated if injectable, especially after reconstitution.

Do I need to cycle it?

Cycling Dihexa is recommended with 4-8 weeks on and 2-4 weeks off to prevent tolerance and potential side effects.

Reported Combinations

Compounds reported to be used alongside Dihexa in community discussions

investigational

Semax

Synergistically promotes cognitive enhancement.

investigational

BPC-157

May enhance neural recovery when combined.

investigational

Noopept

Can potentially enhance learning and memory formation.

Reported Interactions

Interactions reported in literature and community discussions.

Nootropicsmoderate

May enhance or conflict with cognitive enhancing effects.

Alcoholminor

Potential for increased nervousness or anxiety.

NSAIDsminor

Potential for increased bleeding risk.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 6, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

If you are experiencing a medical emergency, call emergency services immediately. If you have questions about medications or supplements, consult a licensed pharmacist or physician.