🌱Emerging

Follistatin 344

RecoveryMuscle Growth
Not FDA Approved

Primary recreational use: Muscle growth enhancement

What is Follistatin 344?

Follistatin 344 (FS-344) is a naturally occurring glycoprotein that inhibits myostatin and activin A, which suppress muscle growth. It is primarily used in research to enhance muscle hypertrophy and regeneration, with potential applications in treating muscular dystrophy. FS-344 is currently banned by WADA and not approved by the FDA. Concerns include its very short half-life and the risk of excessive dosing.

Primary Benefits

Enhances muscle growth. Inhibits myostatin. Activates satellite cells.

How It Works

Follistatin 344 binds and neutralizes myostatin and activin A, preventing their interaction with ActRIIB receptors on muscle cells. This blockade of the TGF-β signaling allows for enhanced muscle growth through hypertrophy and potential satellite cell proliferation.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T exceed 200mcg/day to avoid excessive dosing risks.
  • 2.NEVER use in individuals with active cancer.
  • 3.AVOID using this peptide if you are pregnant or planning to become pregnant.
  • 4.DON'T shake the vial vigorously during reconstitution, as it may denature the protein.
  • 5.NEVER inject if the solution is cloudy after reconstitution.

Who Should NOT Use

  • Active cancer
  • Pregnancy

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Muscle hypertrophy research

limited evidence

Follistatin 344 is used in research settings to investigate its potential to enhance muscle mass and strength by inhibiting myostatin and activin A.

Evidence: Most research involves gene therapy rather than peptide delivery, with very limited human data reported for subcutaneous injections.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
100-200 mcg
Reported Frequency
once daily
Reported Cycle
10-30 days
Reported Route
Subcutaneous

Timing: No established optimal timing

Notes: Effects may not persist between daily doses.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Muscle hypertrophy100 mcgonce dailySubcutaneous injection
Maximize muscle growth200 mcgonce dailySubcutaneous injection

Pharmacokinetics

Half-Life
1.5 hrs
Time to Peak
9 min
Clearance
~7.5 hrs

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
LDL cholesterol increasecommon (1-10%)
Serious / Rare
  • Potential FSH suppression
  • Bone density reduction
Injection-Specific Warnings
  • Use sterile technique to prevent infection

Storage

Temperature
-20°C (lyophilized); 2-8°C (reconstituted)
Reconstituted
Use within 7 days
Shelf Life
Check expiration on the vial
Light Sensitive
No

Harm Reduction Information

Quality Concerns

  • Purity issues
  • Contamination risks

Safety Tips

  • Use sterile/bacteriostatic water for reconstitution
  • Store reconstituted solution in the refrigerator
  • Use within 7 days after reconstitution

Warning Signs to Stop

  • Vision impairment
  • Significant muscle swelling

Seek Medical Help Immediately If

  • Severe vision changes
  • Suspected overdose

Frequently Asked Questions

Common questions about Follistatin 344

How long until I see effects?

Follistatin 344 injectable peptide effects are not well characterized, and results from gene therapy studies have shown changes by 8 weeks.

What time of day should I take it?

Timing is not established for Follistatin 344, but some suggest morning administration due to its short half-life.

How can I minimize side effects?

To minimize side effects of Follistatin 344, never exceed the recommended dose of 200mcg/day and ensure proper sterile technique.

Does tolerance develop?

There is no established information on tolerance development with Follistatin 344 due to limited data on human use.

How should I store it?

Store lyophilized Follistatin 344 at -20°C and the reconstituted solution at 2-8°C; use within 7 days.

Do I need to cycle it?

It is recommended to use Follistatin 344 in cycles of 10-30 days, with a break of 3-4 weeks between cycles to minimize risks.

Can I combine it with other peptides?

Follistatin 344 can be combined with peptides like IGF-1 LR3, BPC-157, and TB-500 for enhanced effects. Monitor combinations closely.

What happens if I miss a dose?

If you miss a dose of Follistatin 344, resume your regular dosing schedule without doubling your next dose.

Reported Combinations

Compounds reported to be used alongside Follistatin 344 in community discussions

investigational

IGF-1 LR3

Enhances muscle growth effects

investigational

BPC-157

Aids in recovery and regeneration

investigational

TB-500

Supports tissue repair and muscle health

Reported Interactions

Interactions reported in literature and community discussions.

ACE inhibitorsmajor

Potential enhanced bone density reduction.

NSAIDsmoderate

Caution advised due to potential impact on muscle growth.

Steroidsmajor

Risk of exaggerated muscle growth and associated complications.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 9, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

If you are experiencing a medical emergency, call emergency services immediately. If you have questions about medications or supplements, consult a licensed pharmacist or physician.