🌱Emerging

FOXO4-DRI

Anti-AgingHealthPerformance
Not FDA Approved

Primary recreational use: Anti-aging and cellular health enhancement

What is FOXO4-DRI?

FOXO4-DRI is a synthetic peptide developed by Dr. Peter de Keizer and colleagues in 2017, specifically designed to eliminate senescent cells by disrupting the FOXO4-p53 interaction. This disruption induces apoptosis in damaged senescent cells, restoring certain cellular functions. While promising in preclinical studies, it remains unapproved for human use, with ongoing safety and efficacy concerns regarding its manipulation of the p53 tumor suppressor pathway.

Primary Benefits

Selective elimination of senescent cells. Potential restoration of tissue function. Anti-aging effects in preclinical models.

How It Works

FOXO4-DRI disrupts the interaction between FOXO4 and p53, a key survival mechanism in senescent cells. This disruption causes p53 to translocate and trigger apoptosis in these cells while sparing healthy cells due to its high selectivity.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T use FOXO4-DRI without consulting a healthcare provider, as it is experimental.
  • 2.DON'T combine with Rapamycin or Quercetin; allow a washout period before use.
  • 3.DON'T exceed dosages derived from mouse studies without professional guidance.
  • 4.DON'T assume stability if storage conditions are not met; maintain at -20°C lyophilized.
  • 5.DON'T shake reconstituted solution; gently swirl to dissolve the peptide.

Who Should NOT Use

  • Potential cancer risk due to p53 pathway interaction
  • Not recommended for healthy individuals under 40

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Senescent cell removal

limited evidence

Research indicates FOXO4-DRI is used to selectively eliminate senescent cells, potentially restoring function and reducing inflammation in tissues.

Evidence: Most evidence is derived from mouse studies demonstrating tissue homeostasis restoration.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
0.025-0.025 mg
Reported Frequency
every other day
Reported Cycle
5-5 days
Reported Route
Subcutaneous

Timing: No specific timing established

Notes: Human dosing is anecdotal and based on murine conversion.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Senescent Cell Clearance~25 mg per injectionEvery other day × 3 dosesSubcutaneous injection

Pharmacokinetics

Half-Life
1 day - 3 days
Time to Peak
4 hours
Clearance
5 days - 15 days

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Burning/itching at injection sitereported (frequency unknown)
Serious / Rare
  • Unknown long-term safety due to lack of human data
Injection-Specific Warnings
  • Avoid shaking reconstituted solution to prevent denaturation

Storage

Temperature
-20°C lyophilized
Reconstituted
2-8°C
Shelf Life
7-10 days after reconstitution
Light Sensitive
No

Harm Reduction Information

Quality Concerns

  • High synthesis cost leading to risks of low-quality or counterfeit products

Safety Tips

  • Ensure sterility of injection tools and reconstitution solvents
  • Follow precise reconstitution protocols to avoid denaturing the peptide
  • Use within recommended time post-reconstitution to maintain potency

Warning Signs to Stop

  • Severe injection site reaction
  • Unexpected systemic side effects

Seek Medical Help Immediately If

  • Any unusual symptoms post-administration

Frequently Asked Questions

Common questions about FOXO4-DRI

How long until I see effects?

FOXO4-DRI effects were seen within 1-4 weeks in mouse studies, but human timelines are unknown.

What time of day should I take it?

There is no established optimal timing for FOXO4-DRI, but effects occur approximately 2-4 hours after administration.

How can I minimize side effects?

To minimize side effects with FOXO4-DRI, avoid concurrent use with Rapamycin or Quercetin and ensure sterility when administering.

Does tolerance develop?

Current research does not indicate tolerance development with FOXO4-DRI in preclinical models.

How should I store it?

Store FOXO4-DRI lyophilized at -20°C and reconstituted at 2-8°C, using it within 7-10 days.

Do I need to cycle it?

Anecdotal protocols suggest cycling FOXO4-DRI every month.

Reported Combinations

Compounds reported to be used alongside FOXO4-DRI in community discussions

recreational

Humanin

Potential compatibility suggested in profiles

Reported Interactions

Interactions reported in literature and community discussions.

Rapamycinmajor

Avoid usage together as it may diminish senolytic effects.

Quercetinmajor

Avoid usage together as it may diminish senolytic effects.

Corticosteroidsmoderate

Potential interaction, proceed with caution.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

Browse All PeptidesAbout Pepbase App

Citations

Last updated: October 6, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

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