⭐Popular

GHK-Cu

Also known as: Copper Peptide, Glycyl-L-histidyl-L-lysine copper

Skin HealthAnti-AgingWeight LossHair Growth
Not FDA Approved

Primary recreational use: Anti-aging and skin regeneration

What is GHK-Cu?

GHK-Cu is a naturally occurring copper-binding peptide found in human plasma, saliva, and urine, discovered in 1973. It is primarily used in skincare for its wound healing and anti-aging properties, showing potential benefits in collagen synthesis and skin regeneration. Despite widespread use in cosmetics, GHK-Cu is not FDA-approved, and many reported benefits come from limited research. Users should be aware of concerns like potential copper toxicity and interactions with existing health conditions.

Primary Benefits

Improves skin elasticity. Accelerates wound healing. Stimulates collagen production.

How It Works

GHK-Cu binds to copper ions and interacts with cell receptors, stimulating collagen and elastin synthesis and promoting glycosaminoglycan production. It modulates inflammation and antioxidative activity, affecting numerous genes involved in skin repair and regeneration.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T use if you have Wilson's disease, due to copper accumulation.
  • 2.AVOID combining with copper supplements to prevent toxicity.
  • 3.DON'T store injectable form at room temperature; refrigerate it.
  • 4.NEVER exceed recommended doses; it may lead to copper toxicity.
  • 5.DON'T apply without sunscreen during daytime use; it can increase photosensitivity.
  • 6.DON'T use if you have active cancer due to angiogenesis concerns.

Who Should NOT Use

  • Wilson's disease
  • Active cancer
  • Severe liver disease

Use Contexts

Different purposes have different protocols, dosing, and considerations

⚡Recreational

Skin Regeneration & Anti-Aging

limited evidence

Used for aiding skin regeneration, reducing wrinkles, and improving skin elasticity.

Evidence: Primarily supported by limited studies and anecdotal reports in the cosmetic industry.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
1-2 mg
Reported Frequency
once daily
Reported Cycle
8-12 weeks
Reported Route
Subcutaneous

Timing: Evening

Notes: Apply topically or inject subcutaneously in recommended concentration.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Initial regeneration1mgonce dailyTopical application
Anti-aging maintenance1-2mgonce dailySubcutaneous injection

Pharmacokinetics

Half-Life
4 min
Time to Peak
3 min
Clearance
~21 min

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Skin irritationreported (frequency unknown)
Injection site reactionsreported (frequency unknown)
Serious / Rare
  • Copper toxicity in case of overdose
Injection-Specific Warnings
  • Use sterile technique to avoid infections

Storage

Temperature
Refrigerate
Reconstituted
Use immediately after reconstitution
Shelf Life
Depends on storage conditions
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Contamination with impurities if sourced from unverified providers.
  • Mislabeling and inconsistency in peptide concentration.

Safety Tips

  • Use bacteriostatic water for reconstitution.
  • Start with the lowest dose and increase gradually to assess tolerance.
  • Rotate injection sites to minimize irritation.
  • Always apply sunscreen during the day when using topically.

Warning Signs to Stop

  • Severe skin irritation
  • Unexpected allergic reactions
  • Dizziness or fainting due to potential copper toxicity

Seek Medical Help Immediately If

  • Uncontrolled skin reactions
  • Signs of copper toxicity (nausea, vomiting, abdominal pain)

Frequently Asked Questions

Common questions about GHK-Cu

How long until I see effects?

With GHK-Cu, users often notice improved skin texture and hydration in 1-2 weeks, with more visible skin changes like reduced fine lines appearing over 4-8 weeks.

What time of day should I take it?

GHK-Cu is best applied in the evening for skin recovery, as tissue repair primarily occurs during sleep.

How can I minimize side effects?

To minimize side effects with GHK-Cu, apply it as directed, conduct a patch test, and use sunscreen to prevent photosensitivity.

Does tolerance develop?

GHK-Cu does not typically lead to tolerance, but cycling protocols are recommended to maintain effectiveness and reduce risks.

How should I store it?

GHK-Cu should be stored in a cool, dry place and refrigerated if in injectable form. Protect from light to maintain stability.

Do I need to cycle it?

Cycling is advised for GHK-Cu use; typical cycles last 8-12 weeks followed by a break to prevent receptor desensitization.

Reported Combinations

Compounds reported to be used alongside GHK-Cu in community discussions

recreational

BPC-157

Combining with BPC-157 enhances healing effects.

recreational

Vitamin C serum

Supports skin brightening and collagen synthesis.

recreational

Microneedling

Improves peptide absorption and enhances skin regeneration effects.

Reported Interactions

Interactions reported in literature and community discussions.

Copper supplementsmajor

May lead to copper toxicity.

Iron chelatorsmoderate

Monitor combination to prevent complications.

Vitamin Cminor

Generally safe, but monitor skin for sensitivity issues.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 9, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

If you are experiencing a medical emergency, call emergency services immediately. If you have questions about medications or supplements, consult a licensed pharmacist or physician.