⭐Popular

Hexarelin

Also known as: Examorelin, HEX

RecoveryHealthPerformanceAnti-AgingMuscle Growth
Not FDA Approved

Primary recreational use: Growth hormone release and muscle growth.

What is Hexarelin?

Hexarelin, also known as Examorelin, is a synthetic hexapeptide growth hormone-releasing peptide developed by Mediolanum Farmaceutici. Originally explored for treating growth hormone deficiency and heart conditions, it is now primarily used for its potent growth hormone release and cardioprotective properties. Although promising in clinical trials, Hexarelin is not FDA approved due to strategic discontinuation. Users should note potential desensitization and elevations in cortisol and prolactin levels.

Primary Benefits

Promotes growth hormone release. Offers cardioprotective effects. Enhances tissue repair and recovery.

How It Works

Hexarelin works by binding to the ghrelin receptor (GHSR-1a) on pituitary somatotrophs, inducing potent growth hormone release. It also uniquely binds to CD36 receptors in cardiac tissue, providing cardioprotective effects through anti-apoptotic and anti-fibrotic mechanisms.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T start with high doses; begin with the lowest effective dose to assess tolerance.
  • 2.AVOID continuous use without breaks to manage desensitization.
  • 3.NEVER inject after meals; administer in a fasted state for optimal results.
  • 4.DON'T store reconstituted solution outside the refrigerator.
  • 5.DON'T use if prone to cortisol or prolactin elevation-related issues.
  • 6.AVOID combining with GH or IGF-1 administration due to blunted effects.
  • 7.DON'T use if you have a history of active cancer due to growth-promoting effects.
  • 8.NEVER share needles or vials to prevent infections.

Who Should NOT Use

  • Active cancer
  • Severe heart disease
  • Uncontrolled hypertension
  • Diabetes

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Growth hormone deficiency and congestive heart failure

strong evidence

Hexarelin has shown potential in clinical trials for treating growth hormone deficiency and providing cardioprotection in heart failure patients. However, development was halted for strategic reasons despite these promising effects.

Evidence: Clinical trials and studies have shown dose-dependent GH release and cardioprotective effects.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
100-200 mcg
Reported Frequency
twice daily
Reported Cycle
8-16 weeks
Reported Route
Subcutaneous

Timing: Administer on an empty stomach, morning and evening

Notes: Cycling off every 4-6 weeks is recommended to prevent desensitization.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Growth hormone optimization100 mcg3x dailySubcutaneous injection
Cardioprotection100-200 mcg2x dailySubcutaneous injection

Pharmacokinetics

Half-Life
1 hr
Time to Peak
30 min
Clearance
~5 hrs

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Increased appetitereported (frequency unknown)
Water retentionreported (frequency unknown)
Tingling/numbnessreported (frequency unknown)
Elevated cortisol and prolactinreported (frequency unknown)
Serious / Rare
  • Secondary hypogonadism due to elevated prolactin
  • Cardiac abnormalities in individuals with existing conditions
Injection-Specific Warnings
  • Injection site reactions possible; rotate sites to minimize risks.

Storage

Temperature
2-8°C
Reconstituted
Refrigerate, use within 4 weeks
Shelf Life
96 weeks unopened
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Potentially impure products from unverified sources
  • Degradation if not properly stored

Safety Tips

  • Use only sterile water for reconstitution and inject subcutaneously.
  • Rotate injection sites to avoid irritation.
  • Store in a refrigerator and keep away from light.

Warning Signs to Stop

  • Severe water retention
  • High blood pressure
  • Acute headache

Seek Medical Help Immediately If

  • Signs of severe cardiac distress
  • New onset of diabetes or glucose intolerance

Frequently Asked Questions

Common questions about Hexarelin

How long until I see effects?

With Hexarelin, growth hormone release peaks around 30 minutes after injection, but changes in body composition may take 4-8 weeks to manifest.

What time of day should I take it?

Hexarelin should be taken in the morning and before bed in a fasted state to maximize growth hormone pulses.

How can I minimize side effects?

To minimize side effects with Hexarelin, adhere to recommended cycling protocols and monitor any elevations in cortisol and prolactin.

Does tolerance develop?

Yes, partial desensitization to Hexarelin occurs with prolonged use, necessitating off-cycles to restore efficacy.

How should I store it?

Hexarelin should be stored in a refrigerator at 2-8°C, especially after reconstitution, and used within 4 weeks.

Do I need to cycle it?

Cycling is crucial with Hexarelin. A typical cycle involves 8-16 weeks of use followed by a 4-6 week break.

Reported Combinations

Compounds reported to be used alongside Hexarelin in community discussions

investigational

CJC-1295

Combined use with Hexarelin can enhance pulsatile GH release.

recreational

Ipamorelin

Less desensitization compared to other GHRPs, complements Hexarelin's effects.

recreational

Exercise

Exercise can enhance GH pulses naturally and improve outcomes.

investigational

Sermorelin

Synergistic in enhancing GH release when combined.

Reported Interactions

Interactions reported in literature and community discussions.

Caffeineminor

May increase jitteriness when combined with GH release.

Beta blockersmoderate

May counteract heart-related benefits of Hexarelin.

GHRP-2moderate

Similar pathway activation can lead to excessive prolactin.

Blood pressure medsmoderate

Monitor for potential hypotensive effects.

Melatoninminor

Safe but may affect sleep quality when taken with GH secretagogues.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 6, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

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