🌱Emerging

Kisspeptin

Also known as: Kisspeptin-10, Kisspeptin-54, Metastin

Sexual HealthHormone Optimization
Investigational

Primary recreational use: Sexual function enhancement

What is Kisspeptin?

Kisspeptin is a neuropeptide encoded by the KISS1 gene, acting as a critical regulator of the reproductive hormone axis. It's being explored for its potential in fertility treatments and reproductive disorders. Although not FDA approved, it is currently under investigation in clinical trials. While generally well-tolerated, long-term hormonal effects remain unknown.

Primary Benefits

Restores reproductive hormone function. Enhances fertility. Improves sexual function.

How It Works

Kisspeptin binds to the KISS1R receptor in the hypothalamus, stimulating the release of GnRH which subsequently triggers the secretion of LH and FSH. This pathway is crucial for the regulation of reproductive hormones such as testosterone and estrogen.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T start with high doses; begin conservatively to assess tolerance.
  • 2.DON'T use kisspeptin daily to avoid receptor desensitization.
  • 3.DON'T use without consulting a healthcare provider concerning fertility treatments.
  • 4.AVOID if pregnant or breastfeeding due to potential hormonal effects.
  • 5.ENSURE sterile injection technique to prevent infection.

Who Should NOT Use

  • Pregnancy and breastfeeding
  • Severe cardiovascular issues

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Fertility support

moderate evidence

Used to enhance fertility by restoring reproductive hormone function, particularly in cases of hypogonadotropic hypogonadism.

Evidence: Studied in various human trials for its ability to induce gonadal steroid production.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
50-150 mcg
Reported Frequency
as needed
Reported Cycle
2-4 weeks
Reported Route
Subcutaneous, Intravenous

Timing: Morning

Notes: Follow specific protocols supervised by a healthcare provider for fertility applications.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Fertility support0.4-1.0 nmol/kgAs directed by physicianSubcutaneous (KP-54)

Pharmacokinetics

Half-Life
28 min
Time to Peak
45 min
Clearance
~2.3 hrs

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Temporary flushingcommon (1-10%)
Mild headachecommon (1-10%)
Nauseacommon (1-10%)
Serious / Rare
  • Cardiovascular effects
Injection-Specific Warnings
  • Use sterile injection technique to prevent infection

Storage

Temperature
Refrigerator at 2-8°C
Reconstituted
Use within 7-14 days
Shelf Life
7-14 days post-reconstitution
Light Sensitive
Yes - protect from light
⚡Recreational

Sexual enhancement

anecdotal evidence

Used to improve sexual function and libido, particularly in cases of hypoactive sexual desire disorder.

Evidence: Community reports indicate improvements in sexual arousal networks.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
100-200 mcg
Reported Frequency
once daily
Reported Cycle
4-6 weeks
Reported Route
Intravenous, Subcutaneous

Timing: Morning

Notes: Cycle with breaks to avoid desensitization.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Sexual function1 nmol/kg/h75 min IV infusion (clinical)IV infusion

Pharmacokinetics

Half-Life
28 min
Time to Peak
45 min
Clearance
~2.3 hrs

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Temporary flushingcommon (1-10%)
Mild headachecommon (1-10%)

Storage

Temperature
Refrigerator at 2-8°C
Reconstituted
Use within 7-14 days
Shelf Life
7-14 days post-reconstitution
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Purity and authenticity issues if sourced non-clinically

Safety Tips

  • Use sterile water for injection
  • Store solution as recommended to avoid degradation
  • Rotate injection sites to prevent tissue damage

Warning Signs to Stop

  • New or worsening headaches
  • Consistent nausea or gastrointestinal upset

Seek Medical Help Immediately If

  • Experiencing prolonged cardiovascular effects

Frequently Asked Questions

Common questions about Kisspeptin

How long until I see effects?

Kisspeptin typically results in an LH surge within 2-5 hours after administration.

What time of day should I take it?

Kisspeptin is best taken in the morning to align with natural reproductive hormone rhythms.

How can I minimize side effects?

To minimize side effects, kisspeptin should be administered at the lowest effective dose under guidance, avoiding daily dosing.

Does tolerance develop?

Yes, kisspeptin can cause receptor desensitization if used daily, so avoid frequent dosing.

How should I store it?

Store kisspeptin in the refrigerator at 2-8°C and use reconstituted solutions within 7-14 days.

Do I need to cycle it?

Yes, cycling is recommended typically lasting 2-4 weeks with breaks to prevent receptor desensitization.

Reported Combinations

Compounds reported to be used alongside Kisspeptin in community discussions

investigational

GnRH

Synergistic effect on reproductive hormone release.

investigational

Testosterone

Compatible for enhanced results in reproductive therapy.

investigational

hCG

Alternative use in triggering ovulation in IVF treatments.

Reported Interactions

Interactions reported in literature and community discussions.

GnRH analogsmajor

Should not be combined due to enhanced gonadal stimulation risk.

Estrogenmoderate

May enhance effects of estrogen; caution advised.

hCGmoderate

Potential increase in physiological effects; monitor closely.

Antihypertensivesminor

Possible interaction by altering blood pressure effects.

Alcoholminor

May increase side effects like flushing.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

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Citations

Last updated: October 2, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

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