Pepbase

Kisspeptin

Also known as: Kisspeptin-10, Kisspeptin-54, Metastin

Investigational
Sexual HealthHormone Optimization

Primary use: Sexual function enhancement

ℹ️

What is Kisspeptin?

Kisspeptin is a neuropeptide encoded by the KISS1 gene, acting as a critical regulator of the reproductive hormone axis. It's being explored for its potential in fertility treatments and reproductive disorders. Although not FDA approved, it is currently under investigation in clinical trials. While generally well-tolerated, long-term hormonal effects remain unknown.

Primary Benefits
  • Restores reproductive hormone function
  • Enhances fertility
  • Improves sexual function
How It Works

Kisspeptin binds to the KISS1R receptor in the hypothalamus, stimulating the release of GnRH which subsequently triggers the secretion of LH and FSH. This pathway is crucial for the regulation of reproductive hormones such as testosterone and estrogen.

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Safety Tips

Precautions reported in community discussions and literature. This is not a complete list. View Full Side Effects Guide →
  • 1DON'T start with high doses; begin conservatively to assess tolerance.
  • 2DON'T use kisspeptin daily to avoid receptor desensitization.
  • 3DON'T use without consulting a healthcare provider concerning fertility treatments.
  • 4AVOID if pregnant or breastfeeding due to potential hormonal effects.
  • 5ENSURE sterile injection technique to prevent infection.

Who Should NOT Use

  • Pregnancy and breastfeeding
  • Severe cardiovascular issues

Dosage & Protocols

Different purposes have different protocols, dosing, and considerations

💉

Fertility support

moderate evidence

Used to enhance fertility by restoring reproductive hormone function, particularly in cases of hypogonadotropic hypogonadism.

Evidence: Studied in various human trials for its ability to induce gonadal steroid production.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Range
50-150 mcg
Frequency
as needed
Cycle
2-4 weeks
Route
Subcutaneous, Intravenous
TimingMorning
NotesFollow specific protocols supervised by a healthcare provider for fertility applications.

📋Community-Reported Protocols

Not recommendations:

The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Fertility support0.4-1.0 nmol/kgAs directed by physicianSubcutaneous (KP-54)

⏱️Pharmacokinetics

Half-Life
28 min
Time to Peak
45 min
Clearance
~2.3 hrs

⚡Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Temporary flushingcommon (1-10%)
Mild headachecommon (1-10%)
Nauseacommon (1-10%)
Serious / Rare
  • • Cardiovascular effects
Injection-Specific Warnings
  • Use sterile injection technique to prevent infection

🧊Storage

Temperature
Refrigerator at 2-8°C
Reconstituted
Use within 7-14 days
Shelf Life
7-14 days post-reconstitution
Light Sensitive
Yes - protect from light
💉

Sexual enhancement

anecdotal evidence

Used to improve sexual function and libido, particularly in cases of hypoactive sexual desire disorder.

Evidence: Community reports indicate improvements in sexual arousal networks.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Range
100-200 mcg
Frequency
once daily
Cycle
4-6 weeks
Route
Intravenous, Subcutaneous
TimingMorning
NotesCycle with breaks to avoid desensitization.

📋Community-Reported Protocols

Not recommendations:

The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Sexual function1 nmol/kg/h75 min IV infusion (clinical)IV infusion

⏱️Pharmacokinetics

Half-Life
28 min
Time to Peak
45 min
Clearance
~2.3 hrs

⚡Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Temporary flushingcommon (1-10%)
Mild headachecommon (1-10%)

🧊Storage

Temperature
Refrigerator at 2-8°C
Reconstituted
Use within 7-14 days
Shelf Life
7-14 days post-reconstitution
Light Sensitive
Yes - protect from light
🛡️

Harm Reduction Information

Quality Concerns

  • Purity and authenticity issues if sourced non-clinically

Safety Tips

  • Use sterile water for injection
  • Store solution as recommended to avoid degradation
  • Rotate injection sites to prevent tissue damage

Warning Signs to Stop

  • New or worsening headaches
  • Consistent nausea or gastrointestinal upset

Seek Medical Help Immediately If

  • Experiencing prolonged cardiovascular effects
❓

Frequently Asked Questions

How long until I see effects?

Kisspeptin typically results in an LH surge within 2-5 hours after administration.

What time of day should I take it?

Kisspeptin is best taken in the morning to align with natural reproductive hormone rhythms.

How can I minimize side effects?

To minimize side effects, kisspeptin should be administered at the lowest effective dose under guidance, avoiding daily dosing.

Does tolerance develop?

Yes, kisspeptin can cause receptor desensitization if used daily, so avoid frequent dosing.

How should I store it?

Store kisspeptin in the refrigerator at 2-8°C and use reconstituted solutions within 7-14 days.

Do I need to cycle it?

Yes, cycling is recommended typically lasting 2-4 weeks with breaks to prevent receptor desensitization.

🔄

Reported Combinations

Compounds reported to be used alongside Kisspeptin in community discussions. Not a recommendation.

investigational

GnRH

Synergistic effect on reproductive hormone release.

investigational

Testosterone

Compatible for enhanced results in reproductive therapy.

investigational

hCG

Alternative use in triggering ovulation in IVF treatments.

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Reported Interactions

Interactions reported in literature and community discussions.

GnRH analogsmajor

Should not be combined due to enhanced gonadal stimulation risk.

Estrogenmoderate

May enhance effects of estrogen; caution advised.

hCGmoderate

Potential increase in physiological effects; monitor closely.

Antihypertensivesminor

Possible interaction by altering blood pressure effects.

Alcoholminor

May increase side effects like flushing.

Reconstitution Guide

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

Browse All PeptidesAbout Pepbase App
📚

Other Sources & Citations

PubMed
Advances in clinical applications of kisspeptin-GnRH pathway in ...
pmc.ncbi.nlm.nih.gov•Updated Oct 2025
PubMed
Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse ...
pmc.ncbi.nlm.nih.gov•Updated Jan 2026
Journal
Discussion
academic.oup.com•Updated Jan 2026
Journal
Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse ...academic.oup.com › jcem › article
academic.oup.com•Updated Jan 2026
PubMed
Kisspeptin And The Female...
pmc.ncbi.nlm.nih.gov•Updated Jan 2026

Last updated: October 2, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

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Calculators and Tools

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