Pepbase

Semax

Also known as: SEMAX, Heptapeptide SEMAX

Not FDA Approved
CognitiveHealthAnti-AgingPerformance

Primary use: Cognitive enhancement and neuroprotection

ℹ️

What is Semax?

Semax is a synthetic heptapeptide derived from an ACTH fragment, originally developed in Russia for stroke recovery. It is known for its nootropic, neuroprotective, and neurorestorative properties, enhancing cognitive function and memory. Semax remains unapproved by the FDA but is approved in Russia for various neurological conditions. Key concerns include the risk of nasal irritation and potential interactions with other medications.

Primary Benefits
  • Enhances cognitive function
  • Improves memory
  • Provides neuroprotection
How It Works

Semax increases BDNF and NGF expression, which enhances neuroplasticity and protects neurons from oxidative stress and excitotoxicity. It modulates the dopaminergic and serotonergic systems, supporting cognitive functions. The peptide also has anti-inflammatory effects in the brain.

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Safety Tips

Precautions reported in community discussions and literature. This is not a complete list. View Full Side Effects Guide →
  • 1DON'T exceed recommended dosages - stick to 200-600 mcg daily.
  • 2AVOID use if experiencing severe nasal irritation.
  • 3NEVER combine with intranasal vasoconstrictors.
  • 4DON'T use continuously without breaks - take a 1-2 week break after 2-4 weeks of use.
  • 5AVOID combining with SSRIs or MAOIs due to potential interactions.
  • 6DON'T administer late in the day to avoid sleep disturbances.
  • 7NEVER use if you have an allergy to the compound.
  • 8DON'T store improperly - refrigerate as required.
  • 9AVOID using expired or contaminated solutions.

Who Should NOT Use

  • Allergy to the compound
  • Concurrent use with MAOIs or SSRIs
  • Severe nasal irritation
  • History of severe psychiatric disorders

Dosage & Protocols

Different purposes have different protocols, dosing, and considerations

💉

Stroke recovery

strong evidence

In Russia, Semax is approved for the treatment of ischemic stroke and is used to aid recovery by enhancing neuroplasticity and cognitive functions.

Evidence: Used clinically in Russia with documented studies showing improvement in stroke recovery and neuroprotection.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Range
6000-6000 mcg
Frequency
every 60 days
Cycle
60-60 days
Route
Intravenous
TimingAs directed
NotesTypically arranged in courses with medical supervision.

📋Community-Reported Protocols

Not recommendations:

The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Stroke recovery6000mcg/day10 days per course with 20-day intervalIntravenous

⏱️Pharmacokinetics

Half-Life
N/A
Time to Peak
N/A
Clearance
N/A

⚡Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Nasal irritationcommon (1-10%)
Increased anxietyuncommon (0.1-1%)

🧊Storage

Temperature
Refrigerated at 2-8°C
Reconstituted
Use or freeze within 24-48 hours
Shelf Life
28 days (if stored properly)
Light Sensitive
Yes - protect from light
💉

Cognitive enhancement

moderate evidence

Used by individuals seeking to enhance memory, attention, and general cognitive function, often through self-administration due to reports of increased BDNF levels and neuroprotective effects.

Evidence: Extensive clinical and anecdotal user reports on cognitive enhancement with regular dosing.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Range
200-600 mcg
Frequency
twice daily
Cycle
14-30 days
Route
Subcutaneous
TimingMorning and early afternoon
NotesTypical use involves alternating nostrils for nasal administration.

📋Community-Reported Protocols

Not recommendations:

The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Cognitive enhancement300-600mcg1-3x dailyIntranasal

⏱️Pharmacokinetics

Half-Life
3 min
Time to Peak
20 min
Clearance
~15 min

⚡Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Nasal irritationcommon (1-10%)
Headacheuncommon (0.1-1%)

🧊Storage

Temperature
Refrigerated at 2-8°C
Reconstituted
Refrigerate and use within 28 days
Shelf Life
28 days
Light Sensitive
Yes - protect from light
🛡️

Harm Reduction Information

Quality Concerns

  • Potential contamination from unregulated sources
  • Degradation if not stored properly
  • Improper concentration labeling

Safety Tips

  • Use sterile technique for administration
  • Alternate nostrils for nasal use
  • Start with the lowest effective dose
  • Store refrigerated and use within recommended timeframes
  • Avoid other nasal vasoconstrictors

Warning Signs to Stop

  • Severe nasal irritation
  • Unexplained headaches
  • Insomnia unresponsive to dose adjustments

Seek Medical Help Immediately If

  • Uncontrolled hypertension
  • Severe allergic reactions
  • Symptoms of serotonin syndrome
❓

Frequently Asked Questions

How long until I see effects?

With Semax, users often report initial cognitive clarity within 15-30 minutes, with peak effects typically occurring in 1-2 hours.

What time of day should I take it?

It's best to take Semax in the morning to maximize cognitive benefits throughout the day and avoid potential sleep disturbances.

How can I minimize side effects?

Minimize side effects of Semax by starting with the lowest effective dose (300 mcg) and avoiding other stimulants.

Does tolerance develop?

There is no strong evidence of tolerance with Semax, but it's advisable to take breaks to maintain effectiveness.

How should I store it?

Store Semax in a refrigerator at 2-8°C, and do not freeze it. Protect from light to maintain stability.

Do I need to cycle it?

Yes, cycle Semax by using it for 2-4 weeks followed by a 1-2 week break.

🔄

Reported Combinations

Compounds reported to be used alongside Semax in community discussions. Not a recommendation.

recreational

Selank

Combines with Semax to enhance focus and reduce anxiety.

recreational

BPC-157

Compatible for neuroprotection and cognitive enhancement.

recreational

Vitamin D

Supports overall brain health and complements neuroprotective actions of Semax.

⚠️

Reported Interactions

Interactions reported in literature and community discussions.

SSRIsmajor

May enhance effects and increase risk of serotonin syndrome.

MAOIsmajor

Increased risk of significant side effects including hypertensive crisis.

Stimulantsmoderate

Potential for enhanced effects; reduce stimulant dose accordingly.

Caffeineminor

Generally safe, but may enhance alertness effects.

Alcoholmoderate

May enhance sedative effects and should be used cautiously.

Reconstitution Guide

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

Browse All PeptidesAbout Pepbase App
📚

Other Sources & Citations

PubMed
The peptide semax affects the expression of genes related to the ...
pmc.ncbi.nlm.nih.gov•Updated Jan 2026
alzdiscovery
Semax Cognitive Vitality For Researchers
alzdiscovery.org•Updated Jan 2026
peptidebiologix
Semax: Comprehensive Research Monograph
peptidebiologix.com•Updated Jan 2026
PubMed
Semax, a Synthetic Regulatory Peptide, Affects Copper ...
pmc.ncbi.nlm.nih.gov•Updated Jan 2026
biotechpharma
Semax | BioTech Pharma
biotechpharma.org•Updated Nov 2025

Last updated: October 5, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

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By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

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