🌱Emerging

SLU-PP-332

Weight LossPerformanceMuscle GrowthAnti-AgingHealth
Not FDA Approved

Primary recreational use: Weight loss and metabolic enhancement

What is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule compound developed at Saint Louis University, functioning as a pan-estrogen-related receptor agonist with a focus on ERRα. Primarily explored for exercise mimetic effects, it offers benefits such as weight loss, enhanced endurance, and improved insulin sensitivity without physical activity. Currently, it remains in the research phase with no FDA approval or human trials, but shows promise in preclinical studies with a good safety profile in animals. Users should be aware of the lack of human safety data, and the potential for uncharacterized effects.

Primary Benefits

Significant weight loss. Improved exercise capacity. Enhanced insulin sensitivity.

How It Works

SLU-PP-332 binds to estrogen-related receptors, predominantly ERRα, triggering the activation of oxidative metabolism and mitochondrial biogenesis pathways. This upregulates genetic expressions linked to energy metabolism, enhancing fatty acid oxidation and ATP production. As a potent exercise mimetic, it upregulates PGC-1α and activates AMPK pathways, promoting enhanced muscle oxidative capacity.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T use without medical supervision as it is not FDA-approved.
  • 2.NEVER inject when recommended for oral use without established human protocols.
  • 3.AVOID purchasing from unverified suppliers due to purity concerns.
  • 4.DON'T take in combination with certain medications without consultation.
  • 5.NEVER store reconstituted solutions improperly or above recommended temperatures.

Who Should NOT Use

  • Uncertain in humans—generally avoid in pregnancy
  • Breastfeeding
  • Known ERR receptor mutations

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Metabolic enhancement and weight loss

strong evidence

SLU-PP-332 is researched for significant weight loss and improved energy expenditure without the need for physical activity.

Evidence: Studies show 12% body weight reduction and improved metabolic markers in animal models, demonstrating strong preclinical efficacy.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
50-50 mg/kg
Reported Frequency
twice daily
Reported Cycle
4-8 weeks
Reported Route
Intravenous, Intramuscular

Timing: Consistent daily administration

Notes: Preclinical studies use this dosing in controlled environments only.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Metabolic enhancement50 mg/kgTwice dailyIntraperitoneal injection

Pharmacokinetics

Half-Life
Unknown
Time to Peak
Unknown
Clearance
Unknown

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Minor changes in plasma cholesterolreported (frequency unknown)
Serious / Rare
  • Potential interactions with diabetes medications
Injection-Specific Warnings
  • Use sterile DMSO for reconstitution
  • Insoluble in water - ensure proper solutions

Storage

Temperature
Refrigerated
Reconstituted
DMSO stock at -20°C to -80°C
Shelf Life
1 month at -20°C, 6 months at -80°C
Light Sensitive
No
🔬Investigational

Improved exercise capacity

moderate evidence

SLU-PP-332 is studied for enhancing physical endurance and oxidative muscle functionality.

Evidence: Animal studies report up to 70% increase in exercise duration and oxidative muscle fiber development.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
50-50 mg/kg
Reported Frequency
once daily
Reported Cycle
4-8 weeks
Reported Route
Intramuscular

Timing: Pre-exercise administration for acute enhancement

Notes: No human protocols exist.

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
Exercise enhancement50 mg/kgPre-exerciseIntramuscular injection

Pharmacokinetics

Half-Life
Unknown
Time to Peak
Unknown
Clearance
Unknown

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Increased muscle oxidative shiftreported (frequency unknown)
Serious / Rare
  • Potential unknown effects in human physiology
Injection-Specific Warnings
  • Ensure proper dosing based on accurate body weight conversions

Storage

Temperature
Refrigerated
Reconstituted
DMSO stock at -80°C
Shelf Life
Up to 1 month
Light Sensitive
Yes - protect from light

Harm Reduction Information

Quality Concerns

  • Purity varies between suppliers—verify with COA
  • Check for contaminants using laboratory assays

Safety Tips

  • Use sterile DMSO for reconstitution
  • Start with lowest possible dose
  • Ensure solution is completely clear
  • Avoid usage if planning pregnancy

Warning Signs to Stop

  • Unanticipated changes in blood sugar
  • Any severe allergic reactions

Seek Medical Help Immediately If

  • Unexpected severe metabolic changes
  • Symptoms consistent with severe diabetes complications

Frequently Asked Questions

Common questions about SLU-PP-332

How long until I see effects?

SLU-PP-332 typically shows effects within 1-2 weeks based on animal studies, but human timelines are unknown.

What time of day should I take it?

As SLU-PP-332 mimics exercise pathways, timing may not critically impact; however, splitting doses could maintain steady levels.

How can I minimize side effects?

Given SLU-PP-332's unknown human safety profile, start with low doses under professional supervision and monitor any adverse symptoms.

Does tolerance develop?

There is no current evidence of tolerance development with SLU-PP-332, but long-term human effects remain unexplored.

How should I store it?

Store DMSO stock solutions of SLU-PP-332 at -20°C (1 month) or -80°C (6 months), and avoid repeated freeze-thaw cycles.

Do I need to cycle it?

Animal studies suggest that continuous usage may be possible, but human cycling protocols have not been established.

Can I combine it with other peptides?

SLU-PP-332 may have interactions with metabolic or exercise-related compounds; professional guidance is advised.

What happens if I miss a dose?

Missing a dose of SLU-PP-332 may reduce its efficiency; resume the next scheduled dose without doubling up.

Reported Combinations

Compounds reported to be used alongside SLU-PP-332 in community discussions

investigational

Tirzepatide

Complementary metabolic effects

investigational

CJC-1295

Enhances recovery and muscle growth

investigational

NAD+

Combines mitochondrial benefits

Reported Interactions

Interactions reported in literature and community discussions.

Metforminmoderate

Potential unpredictable effects on insulin sensitivity

Insulinmajor

Risk of hypoglycemia due to enhanced insulin sensitivity

Semaglutidemoderate

Monitor metabolic responses closely

Common vitaminsminor

Generally safe, but monitor baseline health status

Caffeineminor

Likely safe but minimal interaction expected

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 5, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

If you are experiencing a medical emergency, call emergency services immediately. If you have questions about medications or supplements, consult a licensed pharmacist or physician.