⭐Popular

TB-500

Also known as: Thymosin Beta-4 Fragment

RecoveryHealthAnti-Aging
Not FDA Approved

Primary recreational use: Tissue repair and recovery

What is TB-500?

TB-500 is a synthetic peptide derived from the active region of Thymosin Beta-4, specifically designed to promote tissue repair and regeneration. Initially developed for veterinary use in horses, it has gained traction in human applications for its wound healing and anti-inflammatory properties. While it is not FDA-approved for medical use, it is under investigation in clinical trials for wound healing. Concerns exist regarding its theoretical cancer-promoting potential due to angiogenesis.

Primary Benefits

Accelerated wound healing. Reduced inflammation. Enhanced tissue repair.

How It Works

TB-500 works by binding to and sequestering actin, facilitating cell migration and tissue repair. It promotes angiogenesis, reduces inflammation, and activates stem cell differentiation, predominantly through its role in actin regulation.

Safety Tips

Precautions reported in community discussions and literature. This is not a complete list.

  • 1.DON'T use TB-500 if you have a history of cancer or are currently undergoing cancer treatment.
  • 2.NEVER inject TB-500 without following sterile techniques to avoid infections.
  • 3.AVOID using TB-500 without consulting a healthcare provider if you have immune system disorders.
  • 4.DON'T exceed recommended dosages hoping to expedite results; this increases risk of adverse effects.
  • 5.NEVER store TB-500 without refrigeration once it is reconstituted.

Who Should NOT Use

  • Active cancer
  • Pregnancy
  • Breastfeeding

Use Contexts

Different purposes have different protocols, dosing, and considerations

🔬Investigational

Wound healing

moderate evidence

Experimental users inject TB-500 to enhance systemic tissue repair, focusing on accelerating the healing of dermal and muscular injuries.

Evidence: Various studies report TB-500's potential in accelerating wound healing, with ongoing clinical trials for this purpose.

The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.

Reported Range
2-2.5 mg
Reported Frequency
twice weekly
Reported Cycle
4-6 weeks
Reported Route
Subcutaneous, Intramuscular

Timing: Flexible, best in morning or evening

Notes: Following loading phase, reduce frequency for maintenance; stack with BPC-157 for optimal results

Community-Reported Protocols

Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.

Reported GoalReported DoseReported FrequencyReported Route
General tissue repair2-3mg2x weeklySubcutaneous
Serious injury recovery4-5mg3x weeklySubcutaneous near injury site

Pharmacokinetics

Half-Life
2-3 days
Time to Peak
30 minutes
Clearance
~12.5 hours

Reported Side Effects

This is not a complete list. Other side effects may occur.

Common
Injection site reactionscommon (1-10%)
Headachecommon (1-10%)
Fatigueuncommon (0.1-1%)
Nauseacommon (1-10%)
Serious / Rare
  • Theoretical cancer cell motility risk
Injection-Specific Warnings
  • Use sterile injection technique to prevent infection
  • Avoid during active cancer treatment

Storage

Temperature
Refrigerated at 2-6°C
Reconstituted
Use within 28 days
Shelf Life
Refrigerated solution must be used promptly
Light Sensitive
No

Harm Reduction Information

Quality Concerns

  • Purity may be compromised in non-research settings.
  • Risk of contamination during reconstitution or injection

Safety Tips

  • Practice sterile injection techniques at all times.
  • Use bacteriostatic water for reconstitution.
  • Start with lower doses to gauge response and side effects.

Warning Signs to Stop

  • Unusual lumps or changes in moles
  • Severe allergic reactions like hives or difficulty breathing

Seek Medical Help Immediately If

  • Severe injection site reactions
  • Sudden, severe headaches
  • Signs of an allergic reaction

Frequently Asked Questions

Common questions about TB-500

How long until I see effects?

With TB-500, users typically start noticing reduced inflammation and improved tissue sensation within the first 1-2 weeks of use.

What time of day should I take it?

TB-500 has a flexible timing schedule due to its long half-life, so administration time can be adjusted to your convenience, but consistency is key.

How can I minimize side effects?

To minimize side effects with TB-500, adhere strictly to sterile injection practices and recommended dosing guidelines.

Does tolerance develop?

There is no strong evidence to suggest that users develop tolerance to TB-500. However, cycling is recommended to ensure effectiveness.

How should I store it?

Store TB-500 in a refrigerator between 2-6°C after reconstitution and use within 28 days.

Do I need to cycle it?

Yes, it's advisable to cycle TB-500 to avoid potential issues and maintain its effectiveness.

Reported Combinations

Compounds reported to be used alongside TB-500 in community discussions

investigational

BPC-157

Enhances healing when combined with TB-500; promotes better tissue regeneration.

recreational

CJC-1295

Potential synergistic effects in tissue repair and muscle growth due to increased IGF-1 release.

recreational

IGF-1

May enhance TB-500's regenerative and performance-enhancing effects.

Reported Interactions

Interactions reported in literature and community discussions.

NSAIDsmoderate

May increase bleeding risk; use caution.

Caffeineminor

No known interactions, generally safe.

Blood pressure medicationmoderate

Monitor blood pressure closely; potential alteration in effects.

Reconstitution Calculator

mL
U100 insulin syringe01020304050607080901001mL

100 units = 1 mL

Safety Tips

  • Always consult a licensed medical professional for dosing and reconstitution instructions.
  • Always double check your units. Mixing up mg and mcg can be very dangerous.
  • Make sure to select your syringe type. U-100 and U-50 syringes have different units.
  • Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.

This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.

Explore More Research

Browse our database of peptide research information compiled from published literature and community sources.

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Citations

Last updated: October 3, 2023

Important Disclaimer

AI-Generated Content Notice

The information on this page has been compiled using artificial intelligence (AI) and large language model (LLM) technology from multiple sources including published literature, online communities, and public databases. This content may contain errors, inaccuracies, outdated information, or omissions. We make no guarantees regarding the accuracy, completeness, or reliability of any information presented. You are solely responsible for independently verifying any information before relying on it.

Not Medical Advice

Nothing on this website constitutes medical advice, diagnosis, or treatment recommendations. The information provided is for educational and harm-reduction purposes only. We do not provide individualized dosing guidance or treatment recommendations. Protocols and dosing information shown represent reports from community discussions and published literature—they are not endorsements or recommendations. Always consult with a licensed healthcare professional before making any health-related decisions.

No Endorsement of Use

Pepbase does not endorse, encourage, or recommend the use of any peptide or substance discussed on this website. Many compounds discussed are not approved for human use by the FDA or other regulatory agencies. Some substances may be illegal to possess, sell, or use in your jurisdiction. We do not facilitate or encourage the procurement, distribution, or use of controlled or prescription-only substances. Users are solely responsible for understanding and complying with all applicable laws in their jurisdiction.

Calculators and Tools

Any calculators, estimators, or tools provided on this website are for informational purposes only and produce estimates that may be inaccurate. Errors in calculations can result in serious harm. You are solely responsible for verifying all calculations independently. These tools do not account for individual factors that may affect dosing and should never be relied upon as a substitute for professional medical guidance.

Assumption of Risk

By using this website, you acknowledge that you understand the risks associated with using unregulated substances and that you assume full responsibility for your own health decisions. Pepbase, its creators, contributors, and affiliates disclaim all liability for any harm, injury, or damages arising from the use or misuse of information on this website. Use of any information on this site is entirely at your own risk.

If you are experiencing a medical emergency, call emergency services immediately. If you have questions about medications or supplements, consult a licensed pharmacist or physician.