Tesofensine
Also known as: NS2330
Primary recreational use: Weight loss
What is Tesofensine?
Tesofensine was originally developed for Parkinson's and Alzheimer's disease but found to have significant weight loss effects, leading to its development as an anti-obesity agent. It acts as a triple monoamine reuptake inhibitor and is currently in phase III clinical trials for obesity. While unapproved by the FDA, it remains investigational with concerns about cardiovascular effects and insomnia.
Primary Benefits
Promotes significant weight loss. Suppresses appetite. Improves metabolic markers.
How It Works
Tesofensine inhibits the reuptake of dopamine, norepinephrine, and serotonin by blocking their transporters, thus increasing neurotransmitter levels. This action in the hypothalamus suppresses appetite and increases energy expenditure, aided by silencing of GABAergic neurons that typically promote feeding behavior.
Safety Tips
Precautions reported in community discussions and literature. This is not a complete list.
- 1.DON'T combine Tesofensine with MAOIs, SSRIs, SNRIs, or stimulants.
- 2.AVOID use in individuals with cardiovascular disease or uncontrolled hypertension.
- 3.DON'T take in the evening due to risk of insomnia.
- 4.NEVER use if you have a history of serotonin syndrome.
- 5.DON'T ignore regular cardiovascular monitoring while using Tesofensine.
- 6.DON'T start with a high dose; begin with the lowest effective dose to assess tolerance.
- 7.NEVER use products from unregulated sources without proper verification.
Use Contexts
Different purposes have different protocols, dosing, and considerations
Weight loss in obesity management
moderate evidenceTesofensine is being studied primarily for its effects on weight loss, especially in obese populations.
Evidence: Phase 2 and 3 trials demonstrate significant weight loss effects.
The following are ranges reported in published literature and community discussions. These are NOT recommendations or medical advice.
Timing: Morning
Notes: Morning dosing reduces insomnia risk.
Community-Reported Protocols
Not recommendations: The following protocols are compiled from online communities and published literature. Pepbase does not endorse, recommend, or verify these protocols. They are provided for informational purposes only. Individual responses vary significantly. Consult a licensed medical professional before any use.
| Reported Goal | Reported Dose | Reported Frequency | Reported Route |
|---|---|---|---|
| Standard Weight Loss | 0.5mg | Once daily | Oral |
Pharmacokinetics
Reported Side Effects
This is not a complete list. Other side effects may occur.
Common
Serious / Rare
- Cardiovascular events
Injection-Specific Warnings
- Use sterile technique for subcutaneous injections.
Storage
Harm Reduction Information
Quality Concerns
- Variable purity in compounded products
- Unverified sources may lack testing
Safety Tips
- Start with a conservative dose to assess tolerance.
- Use stable dry storage to prevent moisture degradation.
Warning Signs to Stop
- Severe insomnia
- Uncontrolled hypertension
- Significant cardiovascular changes
Seek Medical Help Immediately If
- Chest pain
- Severe psychiatric symptoms
- Uncontrolled high blood pressure
Frequently Asked Questions
Common questions about Tesofensine
How long until I see effects?
You may notice appetite reduction within the first week of using Tesofensine, with significant weight loss typically starting in weeks 2-4.
What time of day should I take it?
Tesofensine should be taken in the morning to minimize insomnia and ensure even blood levels.
How can I minimize side effects?
To minimize side effects of Tesofensine, start with a low dose and avoid taking it in the evening to reduce the risk of insomnia.
Does tolerance develop?
Tolerance to the anorexigenic effects of Tesofensine may develop, although weight loss effects tend not to diminish over time.
How should I store it?
Tesofensine should be stored at room temperature, protected from moisture.
Do I need to cycle it?
There are no standard recommendations for cycling Tesofensine, but due to its long half-life, consistent daily dosing is less critical.
Can I combine it with other peptides?
There's insufficient data on combining Tesofensine with peptides like Semaglutide, so caution is advised.
Reported Combinations
Compounds reported to be used alongside Tesofensine in community discussions
5-HTP
Potential to prolong weight loss effects
Alpha lipoic acid
May enhance metabolic benefits
Physical exercise
Increases overall weight loss effectiveness
Reported Interactions
Interactions reported in literature and community discussions.
Increased risk of serotonin syndrome.
Potential for severe interactions with increased side effects.
Contraindicated due to high risk of serotonin syndrome.
May exacerbate cardiovascular side effects.
May increase the risk of insomnia and jitteriness.
Reconstitution Calculator
100 units = 1 mL
Safety Tips
- Always consult a licensed medical professional for dosing and reconstitution instructions.
- Always double check your units. Mixing up mg and mcg can be very dangerous.
- Make sure to select your syringe type. U-100 and U-50 syringes have different units.
- Ensure you're not adding more BAC than your vial can hold. Most vials have maximum capacities listed.
This calculator is for informational and educational purposes only. It does not provide medical advice, dosing recommendations, or safety determinations. Reference ranges shown are compiled from publicly available sources and are not a substitute for guidance from a licensed healthcare professional.
Legal Status by Region
Regulatory status varies by country
USA
Investigational New Drug
UK
Investigational
EU
Investigational
Australia
Investigational
Canada
Investigational
Explore More Research
Browse our database of peptide research information compiled from published literature and community sources.
Citations
Last updated: October 5, 2023